The second edition of the book is thoroughly revised as per CBME curriculum of NMC 2024. The authors have made an effort to provide a simple and exclusive case based clinical biochemistry book enriched with clinical discussion, short answers with the specified competencies. While developing phase of case studies in clinical biochemistry special precaution has to be taken to keep explanation and narrations simple. In the light of upcoming NEXT pre-PG entrance examination, all the case discussions are crisp, to the point with diagrammatic representation of clinical signs and symptoms. Thoroughly revised as per the latest CBME curriculum by NMC (2024). Clinical cases are an essential component of both internal and summative assessment for MBBS exams as per new CBME curriculum led by NMC. Clinical cases are illustrated in a manner that it will also be helpful in NExT Pre-PG, Foreign Medical Graduate entrance, and medical licensing examinations. Simple and comprehensible language for easy understanding.